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Xc system is crucial in regulating ferroptosis and SLC7A11 facilitates the exchange of extracellular cystine and intracellular glutamate across the plasma membrane, as well as the reduction of cystine to cysteine within cells, which is essential for GSH production [75]

Manganese supports enzymes involved in neurotransmitter synthesis and antioxidant defense, which are crucial for brain health, and it may help mitigate oxidative stress and neuroinflammationboth of which are implicated in seizure disorders

discussion 37-18

& Whikehart, D

Nicin L, Wagner JUG, Luxan G, Dimmeler S (2022) Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart