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The reclassification to Category 2 may serve as a catalyst for pharmaceutical companies and research institutions to invest in the rigorous clinical trials required for formal FDA approval

Surface modification Surface modification or conjugation of active functional groups to nanoparticles is another strategy to modulate their permeability to the BBB when optimizing the nanoparticles' own physicochemical properties is not sufficient to achieve the desired effect

Post-administration feeding should be delayed 3045 minutes minimum

It remains unproven whether the differing molecular signatures are due to the route (bypassing the blood-brain barrier vs

Pain and stress activate the vagus nerve, which plays a crucial role in transmitting sensory signals from the GI tract to the brainstem, particularly to the nucleus tractus solitarius (NTS)