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The retrospective and single-centered study protocol was approved by the Research Ethics Committee of Tohoku University (no

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Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME/CFS), is a complex and often misunderstood condition characterized by profound fatigue that doesnt improve with rest and worsens with physical or mental exertion

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People with gastrointestinal diseases affecting nutrient absorption may require high doses of vitamin B12 supplements