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Vanda CEO Mihael Polymeropoulos called the drug a familiar therapeutic agent that offers flexible dosing with a well-known safety profile. April 1 Product: AstraZenecas Voydeya Indication: Paroxysmal nocturnal haemoglobinuria AstraZeneca kicked off April with a win for its rare disease portfolio as the FDA approved Voydeya, an oral, first-in-class factor D inhibitor to treat a subset of patients with paroxysmal nocturnal haemoglobinuria (PNH)

Mitochondrial complex I inhibition by Homoharringtonine: a novel strategy for suppression of chronic myeloid leukemia

The summary data in Figure 2D demonstrate a substantially higher frequency of classical monocytes showing FLICA + ASC-speck + formation in COVID-19 patients than HC subjects, which positively correlated with plasma IL-18 levels ( Figure 2E )