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The ideal therapeutic compound for TBI and CNS diseases should have PK-PD criteria such as smaller molecular weight, moderately lipophilic, low plasma protein binding affinity, higher distribution volume, and serve as weak ligand of P-glycoprotein or another efflux pump located at the BCB [44]

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The most accurate interpretation is: 5-Amino-1MQ demonstrates promising metabolic activity in laboratory research, but its clinical effectiveness in humans remains uncertain

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