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Quickstart Highlights Cagrilintide is a long-acting amylin analog studied for appetite control and weight management [1] it imitates the satiety hormone amylin to blunt hunger and slow gastric emptying [2]

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In the present study, we have, therefore, utilized these unique samples and applied an optimized triple-label immunohistochemical protocol for comparing the localization of GPX1 in beta and alpha cells and for estimating its level and relative expression in the two cell-types in high-quality human pancreatic sections from diabetic and non-diabetic deceased donors, supplied by the Network for Pancreatic Organ Donors with Diabetes (nPOD) and the Exeter Archival Diabetes Biobank (EADB) (Morgan and Richardson 2018

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Prostacyclin synthase (PGI 2 synthase) is another important target of peroxynitrite that is inactivated by a specific nitration of Tyr-430 (1130)