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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

The combination of GLP-1 receptor agonists with amylin analogues or future ghrelin receptor-targeting therapies may provide greater reductions in body weight and adiposity than monotherapy