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Eligible publications were reviewed by two authors independently and relevant details were extracted which related to the potential impact of e-cigarettes on the environment: namely their components, their chemical contaminants, their waste issues, and pollution (Figure 1)

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Themed answers each start with a synonym of BREEZE: 58A Piece of cake! and apt description of the starts of 17-, 22-, 36- and 46-Across

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This may represent a lost opportunity for encouraging quitting smoking by providing a potentially attractive option to help smokers to quit