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The glucose deprivation, MDM2, can be upregulated by mTOR via p53-dependent manner, which could promote cellular response to these environmental alterations 35

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Mary-Ann McKibben, consultant in public health at PHW, said: "While vaping is safer than smoking for adults, it is not riskfree and we do not yet have a comprehensive understanding of the long-term health effects." She called the ban an "important step" towards preventing a generation of young people addicted to nicotine