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One commenter requested that CMS seek alternative, more current data sources to rebase and revise the MEI if the AMA PPIS data proves insufficient, stating that the 2017-based MEI derived predominantly from the 2017 US Census Bureau's Service Annual Survey (SAS) are outdated and should not be used for updates

Cerebrolysin has the largest clinical evidence base, including randomized controlled trials (CAPTAIN I and II), cohort studies, and a meta-analysis spanning 8,749 patients

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