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These effects have occurred mainly in patients with preexisting renal disease

The disease is mediated by IgG Abs that bind components of the neuromuscular junctions

Cell Metabolism 28(3):516-524. [doi.org]

The rest of this article covers exactly how much 5-Amino-1MQ per day produces NNMT inhibition without receptor saturation, how reconstitution volume changes effective dose per injection, and what preparation mistakes negate the benefit entirely