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Because patients with COVID-19 have evidence of systemic inflammation, often have their course complicated by acute respiratory distress syndrome, and may have respiratory mucus buildup limiting adequate airflow, systemic or aerosolized N -acetylcysteine (or both) may be beneficial in this specific patient population

Long-term safety data remains unavailable, so extended use should be approached carefully, especially outside controlled research settings

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The reactivity of several persulfides of biological interest is being unveiled

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