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Moreover, inflammatory factors activate signaling pathways within endothelial cells, such as the nuclear factor-B (NF-B) pathway, further upregulating the expression of adhesion molecules (such as ICAM-1 and VCAM-1), which facilitates leukocyte adhesion and transmigration across the endothelium, thereby exacerbating BSCB damage

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Luo X, Zhou X, Lin X, Qin X, Zhang T, Wang J, et al

Thatoi, S

Thus, large-scale experiments are required to fully establish the biosafety and reliability of ferroptosis-targeting agents, while verifying their role in RCC progression and treatment, before clinical translation