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1 Several antidepressant medications are known to increase systemic levels of serotonin, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), some opioids, antihistamines, serotonin-releasing illicit drugs, and over-the-counter herbal medications 1 (Figure 1)