Recent studies looking at the telomeric proteome during replication observed high levels of histone protein H1 at telomeres during replication (Lin et al 2021), and cells that had H1 depleted through knockout experiments are sensitive to DNA damage and double strand breaks (Murga et al 2007)
These effects are typically temporary and tend to diminish once the treatment is discontinued or the dose is adjusted
Global Events & Experiences Access exclusive gatherings like the NYC Mastermind and the Cannes Longevity Summit & Awards Who Its For Doctors Join the club, get certified, grow your practice Health Systems Implement clinical longevity programs Brands & Startups Validate products, find advisors, run trials Investors Gain early access to insights, doctors, and deal flow Subscribe to the Longevity Docs Newsletter Stay connected with the backstage of the Longevity Docs community, a network of over 400 physicians spanning 50 countries, united in our mission to democratize longevity medicine
For example, the choroid plexus, a structure in the brain that produces cerebrospinal fluid, may serve as a gateway for monocyte infiltration into the CNS [170]
That said, a PCAC vote is advisory, not binding, meaning real-world access for patients hasn't changed
