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The term non-hydrogen substituent refers to a substituent that is not made up solely of hydrogen

Oral cobalamin is a safe and effective way of supplementing the vitamin even in deficiency states, including pernicious anemia

Homozygous mice showed abnormal tau phosphorylation and intraneuronal A accumulation in the hippocampus and cerebral cortex at 8 months, with heterozygotes exhibiting slight A accumulation at 24 months

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

Exposure to the CYP2D6-mediated primary metabolite, dextrorphan, also remained unaffected (Figure 2, Table 1)