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Avoid standard oral B12 supplements under 1000 micrograms they fail to correct deficiency in most cases

The general math works as follows: dividing the total content of the vial by the volume of bacteriostatic water added gives the concentration per milliliter

the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use

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