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This appetite-neutral characteristic distinguishes AOD-9604 from medications like GLP-1 agonists (Semaglutide, Tirzepatide) that work primarily through appetite suppression

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In contrast, CCM provides detailed imaging of corneal nerve fibers, and Sudoscan assesses sweat gland function, both offering more precise early detection of neuropathy [48]

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To this fact it must be added lipid and glucose dysregulation are common in BD patients, even before the diagnosis and treatment [247] and atypical antipsychotics can worsen these alterations