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10.1016/j.biopha.2020.110092 67 GaschlerM

Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family

These degradation products, mainly aldehydes, such as malonaldehyde, hexanal, 4-hydroxynonenal or acrolein, have biological roles in cellular signaling, in normal and pathological conditions and in regulation of cell cycle 28

Exceeding recommended doses (typically above 1,000 mg/day) increases the likelihood of digestive side effects such as bloating, cramping, and loose stools