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Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucose-dependent insulinotropicGLP-1RAs, have evolved from metabolic therapies to agents with either proven or potential protective effects on the kidney and heart

Similar to RMT, the BBB entry occurs with an invagination of cell membrane holding the bonded molecule, followed by endosomal formation and transport from the luminal to the abluminal side, and finally with the exocytosis of the cargo (Figure 3E

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These results suggest that GpoA is critical not only for resistance to oxidative stress but also for effective invasion and systemic dissemination during infection