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The inflammation is believed to originate from adipose tissue (where body fat is stored), which secretes hormones and chemical messengers that trigger inflammation and influence immune cell activity

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Moreover, IGF-1 can promote M2 microglial polarization via the inhibition of TLR4/NF-B signaling transduction and lead to the elevation of neuroprotection factors such as IL-10 and TGF- to attenuate microglia-mediated inflammation (Sun et al

In zebrafish models, the deletion of dnmt3 caused severe defects in the brain and retina, severely impairing normal neurogenesis