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For instance, when we first alerted members to the dangers of high homocysteine levels, standard reference ranges indicated that blood levels of up to 15 mol/L were acceptable

Ophthalmology 117 , 15381546 (2010)

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iPSCs must undergo rigorous characterization to ensure their pluripotent state and genomic integrity

Apart from clearance functions, high levels of acidification in synapses are also required for synaptic vesicle fusion and recycling 106 during neurotransmitter exocytic release 107 , which may explain why lysosomal enhancement via pH correction ameliorates synaptic dysfunction and cognition, as well as clearance of aggregate-prone proteins, in mouse models of AD and PD 94,108,109