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2025 Oct 12

Fassett RG, Robertson IK, Ball MJ, Geraghty DP, Coombes JS

(2022) p:2031500

By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1)