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The key residues in both GSH_a and GSH_b binding modes are located in the C1 region (N259 and E255), it is evident that for GSH, the C1 region of mTYR is the critical binding area

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These include inhibiting DNA binding activity of EBNA1 (351, 352), disrupting homodimerization (353), blocking its interaction with key host cellular proteins, such as USP7, CK2 or targeting its oncogenic partners, such as MDM2 (354)

Case Rep Neurol Med 2013