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Furthermore, the long non-coding (lnc)RNA KCTD21-AS1, modified by METTL14-mediated N6-methyladenosine methylation, acts as a competing endogenous RNA for miR-519d-5p to regulate CD47 and TIPRL expression, thereby modulating macrophage phagocytosis and autophagy in LC cells (24)

This reaction simultaneously converts GSH into its oxidized form, glutathione disulfide (GSSG) [37]

Classification and chemical structures of ADC linkers [2] As of December 2025, 21 ADCs have received global approval (Table 1)

however, the dual role that these cells and their released products partly explain the difficulties in the available therapies directed against these and other inflammatory mediators [40,43]

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain