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Together, the two hormones form the so-called GH/IGF-1 axis which plays a major role at every age

Clinical research involving approximately 900 participants across six human trials specifically measured serum IGF-1 concentrations and found no changes with AOD-9604 treatment at doses up to 1 mg per day and beyond

Reddy PH, Manczak M, Mao P, Calkins MJ, Reddy AP, Shirendeb U (2010) Amyloid-beta and mitochondria in aging and Alzheimers disease: implications for synaptic damage and cognitive decline

Similar favorable results have also been reported in muscular dystrophy mice models, where sulforaphane treatment alleviated muscle inflammation in dystrophin-deficient mdx mice (Sun et al., 2015b)

Women who are pregnant or breastfeeding should not use goldenseal, and it should not be given to infants