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Escape mechanisms from antiangiogenic therapy: an immune cells perspective

These dynamics were captured by a significant drop in the acidic-to-neutral mucin ratio during demyelination (p = 0.0462), which normalized upon remyelination, underscoring transient vulnerability of the mucus phenotype (p = 0.0202) ( Figure 2H )

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For THP-1-derived macrophages, cells were differentiated into M0 macrophages using PMA and subsequently co-cultured with control or inflammatory SV-HUC-1 cells 46

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