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In animal studies, LC was found to increase the levels of circulating insulin-like growth factor-1 (IGF-1), which consequently led to the activation of protein kinase B (Akt) and the mammalian target of rapamycin (mTOR) []

Concerning gene expression analysis, the DESeq2 package for R was used to evaluate the differential expression between conditions using the Wald Test

Betaine uptake systems have been described in E

Although some of the manifestations of FAS may be related to co-existent or alcohol induced Zn deficiency, further research is needed to identify its significance in brain outcomes in the affected neonates