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Together, these results demonstrate that GCLC has a non-canonical role in ferroptosis to balance the glutamate pool to protect against ferroptosis under cystine starvation (Figure S5E)

This is the kind of analysis we do internally when advising research partners on protocol design

An important example is insulin resistance: reduced glucose uptake in cancer patients compared with healthy controls during an euglycemic hyperinsulinemic glucose clamp has commonly been observed not only during 7, 8 but also before weight loss or malnutrition

2024 Jan;119(1):49-57

MMAE also lowers the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine (CRE) levels that were otherwise elevated in the DLA control animals