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Description

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and b cells

This hypothesis is supported by a tight connection between extrahepatic vitamin K deficiency and poor outcome [317]

TAFs interact with stromal cells by secreting growth factors, cytokines, and chemokines, including IL6, TGF, and CCL2, to amplify immune evasion systems, attracting immunosuppressive cells into the tumor microenvironment, and they also form a network of proinflammatory mediators at the tumor site