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doi: 10.1210/jc.2016-3222 144 PinartM.DtschA.SchlichtK.LaudesM.BouwmanJ.ForslundS

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we observed a strong growth defect and massive cell death in the LHON-edited cells, but not in the SILENT-edited cells (population doublings per day: LHON 0.64 0.11, SILENT 0.52 0.07

doi:10.1007/BF01263443 16

8.5 Cell-free strategies In recent years, researchers have discovered that extracellular vesicles (EVs) secreted by stem cells, such as exosomes and microvesicles, possess immunomodulatory functions similar to stem cells (Yu et al., 2014)