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First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: A proposal to chemists

Abstract Background Cholestasis is an important predisposing factor for hepatocyte damage, liver fibrosis, primary biliary cirrhosis, and even liver failure

Nuclear IGF-IR regulates gene expression While IGF-IR is usually localized at the plasma membrane in normal cells, it often translocates into the cytoplasm and nucleus in cancer cells even though it does not have the nuclear localization signal [78,79,80]

*Correspondence: Vishwanath Venketaraman, [email protected] These authors have contributed equally to this work This article was submitted to Pharmacology of Infectious Diseases, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Thus, miR-26a could be described as a tumor-suppressive miRNA in osteosarcoma and, interestingly, IGF1 was shown to be a direct target of miR-26a (76)