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This section discusses MS pathogenesis with emphasis on neuroinflammation and BBB disruption, the roles of dysfunctional innate immune cells, adaptive T and B cell dysregulation, and the resultant pathological outcomes

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, et al

Genome Biol 4:R20

Intestine and gastrointestinal system The historical context of BPC-157 (isolated from gastric juice) explains its most documented gastrointestinal application: gastric ulcers, colitis, and Crohn's disease in animal models

In brief, it is suggested that an elevated secretion of pro-inflammatory cytokines and diminished hepatoprotection by IL-6 might contribute to TVX-induced hepatotoxicity in the model, whereas the non-DILI reference drug LVX did not alter the cytokine profiles