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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F et al

Baseline and ongoing monitoring: Before initiating GLP-1/GIP therapy, consider measuring baseline B12 levels, particularly in patients concurrently taking metformin, those with previous bariatric surgery, individuals following plant-based diets, or those with malabsorption conditions

By inhibiting -glucosidase, RES reduces postprandial blood glucose spikes, contributing to improved glycemic control ( in vitro cellular experiment a RES intervention can alleviate insulin resistance (IR) and enhance the activation of AMPK ( RES can exert its anti-diabetic effects through the coordination of four mechanisms: inhibiting glucosidase activity, improving IR, protecting pancreatic -cells, and inhibiting gluconeogenesis via signaling pathways such as PI3K/serinethreonine protein kinase AKT

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In the future, prolonged monitoring of GABA and GABA/Glx would be helpful to illustrate this dynamic change of these neurotransmitters during the GABA switch associated with the neurodevelopment and bumetanide treatment