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GH secretagogues work best on an empty stomach, ideally 2-3 hours after eating and 30 minutes before sleep

Endocr Rev 28(1):84116 Gu W, Winters KA, Motani AS, Komorowski R, Zhang Y, Liu Q et al (2010) Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor

The 4-week minimum at each phase exists because some side effects have delayed onset