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In obese mice, combining ERR activation with dietary control yields additive improvements in fat mass and hepatic features, suggesting compatibility with lifestyle or other pharmacological interventions

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Moreover, elevated homocysteine levels have been associated with enhanced in vivo lipid and protein oxidation in humans, as suggested by the correlation obtained between plasma homocysteine and F 2 -isoprostanes, relevant biomarkers of nonenzymatic peroxidation (Ventura et al, 2000