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Biomarker-based inclusion criteria, early-phase safety trials of PAD4 inhibitors or DNase in well-characterized PCOS subgroups, and careful selection of composite endpoints capturing metabolic, reproductive, and vascular outcomes will be essential

Symptoms of vitamin B12 deficiency: extreme tiredness a lack of energy pins and needles a sore and red tongue mouth ulcers muscle weakness problems with your vision psychological problems, which can range from mild depression or anxiety to confusion and dementia problems with memory, understanding and judgement Causes of a vitamin B12 deficiency: pernicious anaemia a lack of these vitamins in your diet medicine certain medicines, including anticonvulsants and proton pump inhibitors (PPIs), can affect how much of these vitamins your body absorbs

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Additionally, the intracellular GSH was not changed at 12 hours between control and CSE but by 24 and 48 hours there was significantly increased intracellular GSH in the CSE exposed cells (Figure 1B)