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The findings of a clinical trial demonstrated that silymarin administration diminished the incidence of anti-tuberculosis drugs induced-liver injury which can be attributed to a lower reduction in the level of superoxide dismutase compared to the control group [146]

This treatment is not considered painful

However more researches suggested that it was oxidized LDL instead of heme itself ascribed as the cause for the induction of heme oxygenase-1 and ferritin, since when catalyzing the oxidation of LDL, heme itself underwent degradation (Nath et al., 1995

Monami M, Candido R, Pintaudi B, Targher G, Mannucci E

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