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In the nineteenth century, Russian physicians documented its health-promoting effects, including immune modulation, antimicrobial activity, lactose digestion, cholesterol metabolism, and possible anticancer properties

[314] A moderate dose of caffeine enhances rapid eye movements' kinematics, such as saccade velocities and quick phases of optokinetic nystagmus, in unfatigued individuals, without affecting pursuit eye movements or visual perception, suggesting that caffeine's influence on oculomotor control may be mediated by changes in central catecholamines even in non-fatigued conditions

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Conversely, the no loading dose regimen resulted in a steady increase in vitamin B12 levels from 224 to 717 pmol/L over 90 days