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Diabetes Prevention Program Research Group, Knowler WC, Fowler SE, et al

Elife 2015;4:e10308

Cheng WL, Yang Y, Zhang XJ, Guo J, Gong J, Gong FH, She ZG, Huang Z, Xia H, Li H

Understanding pKa Understanding pKa values requires analyzing the molecular structure and the stability of conjugate bases

The second cleavage is performed in the intracellular domain, by a -secretase and yields a fragment that is destroyed in the proteasome (Hammond et al., 2001)(Figure 3)