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In contrast, DFO treatment at concentrations 2500-fold (500 mol/L) and 5000-fold (1000 mol/L) higher than DHA resulted in only modest reductions, with infection rates decreasing to 1.10% ( = 0.10%) and 1.0% ( = 0.20%), respectively

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The peptides primary biological function relates to copper binding and delivery, but research has revealed extensive additional activities including gene expression regulation, protease modulation, and cellular signaling effects

Glycocalyx disruption can precipitate several detrimental consequences: (1) Vasomotor dysfunction, wherein endothelial structural damage impairs mechanotransduction, leading to aberrant release of NO and endothelin (ET), thereby compromising vascular regulation