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Description

These findings suggest that NNMT inhibition may modulate the metabolic responses to physical activity by altering cellular energy metabolism across multiple tissue types

[DOI] [PubMed] [Google Scholar] Glass 1961 Glass GB, Skeggs HR, Lee DH, Jones EL, Hardy WW

They activate different second messenger systems

Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)