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Oocyte-derived EVs (oo-EVs) deliver crucial cargo, such as miRNAs (e.g., miR-205), to granulosa cells, repressing genes like SOCS2 and thereby enhancing cell proliferation and follicular integrity (Esfandyari et al., 2021

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doi: 10.1080/00207454.2021.1962863

Targeting HIF-1 translation PI3K inhibition Buparlisib (BKM120) As the most clinically advanced agent of all PI3K-inhibiting medicines, Buparlisib is a potent, selective, orally bioavailable class I pan-PI3K inhibitor with properties against p110-, -, -, and - enzymes at IC 50 values of 52 M, 166 M, 116 M, and 262 M, respectively [247]