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Risk of bias (quality) assessment Two authors (AJ and SS-B) independently assessed the risk of bias of the trials according to version 2.0 of the Cochrane tool for risk of bias assessment (Reference Higgins, Thomas and Chandler13)

96 MBK-103 (LY4170156) comprises an Fc-attenuated humanized IgG1 antibody targeting FR and a novel polysarcosine hydrophilic masking entity, allowing the conjugation of the exatecan payload with a DAR of 8 97 (Figure 4)