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All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases

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This allows the body to resume the critical tasks of methylating DNA, regulating gene expression, and synthesizing the neurotransmitters necessary for emotional well-being and cognitive clarity

The research behind the guidance points most often to the four or five year mark and to doses around 1,500 milligrams a day or more

Other Stimulants: Combining Phentermine with other stimulant medications can significantly increase the risk of cardiovascular side effects