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Another analysis noted contradictory results across studies, with specific trials showing improved cognitive test scores in metformin-treated patients, while others showed no effect or even a decline [176,184]

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Casey SC, Amedei A, Aquilano K, Azmi AS, Benencia F, Bhakta D, Bilsland AE, Boosani CS, Chen S, Ciriolo MR, Crawford S

This is a tribe who traces its ancestry back to the Ice Age, and people ask me all the time, Oh my gosh, what are the Quileute going to do when Twilight s gone? And Im thinking, Yeah, they do trace their ancestry back to the Ice Age

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First, KEAP1 has been shown to have complex interactions with various other proteins besides NRF2 (Hushpulian et al., 2021) and concerns about potential side effects arise from the diverse array of cellular processes covered by KEAP1 interactor proteins, involving DNA replication, cytoskeletal dynamics, transcription, and apoptosis