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barbadense , there is a down-regulation of the drought-tolerant gene gbMYB5, thus enhancing oxidative damage under drought stress due to reduction in antioxidant activities, i.e., GST, CAT, POD, and SOD (Chen et al

Off-target effects and specificity Another significant challenge in implementing RNAi in crops is the possibility of off-target effects, where small interfering RNAs (siRNAs) or microRNAs (miRNAs) derived from double-stranded RNA (dsRNA) attach to and silence non-target genes

Therefore, we need new therapeutic strategies to tackle this global problem

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