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In vitro studies have demonstrated that these cytokines stimulate the production of endothelin-1, which is associated with vascular dysfunction (137)

Osteopontin, secreted by a variety of cells, is the molecule that links inflammation and liver recovery/regeneration and, in addition to being an extracellular matrix protein is also a pro-inflammatory cytokine and is considered to have the greatest prognostic value in predicting liver transplantation in patients with DILI compared to other promising biomarkers such as ccK18/K18 and MCSFR [269]

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