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Eradication typically requires triple therapy two antibiotics plus an acid-reducing drug.38 A 2010 randomized trial compared Nigella sativa seed powder (2g/day) plus omeprazole to standard triple therapy.29 Eradication rates with black seed were comparable to triple therapy, suggesting a potential role as an alternative when antibiotics arent tolerated

BM-MSCs or BM-MSCs-exosome co-treatment caused anti-apoptotic impacts via a meaningful reduction in Bax/Bcl2 ratio and a rise in the expression of mitochondrial mitophagy genes, including Parkin RBR E3 Ubiquitin Protein Ligase ( Parkin ), phosphatase and tensin homolog (PTEN)-induced putative kinase 1 ( PINK1 ), unc-51 like autophagy activating kinase 1 ( ULK1 ), B-cell lymphoma 2/adenovirus E1B 19 kDa protein-interacting protein 3 ( BNIP3L ), autophagy related gene ( ATG5 ), ATG7 and ATG12

The supernatant was reacted with 10 mM dithiobis-(2-nitrobenzoic acid) in 0.2 M TrisHCl (pH 8.2)

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