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Notch signals are involved in multiple cellular processes, including cell survival, differentiation, apoptosis, and regeneration (Siebel and Lendahl 2017)

This cascade contributes to reduced RBC lifespan, anemia, and impaired tissue oxygenation factors that negatively influence health span and longevity [33,34]

The enzyme methylene-tetrahydrofolate reducate (MTHFR), then converts the 5,10-methylene group to 5-methyl-THFwhich it transports of the folate cycle into the methylation cycle, in this way a single folate molecule can be recycled over 1000 times into and out of the folate cycle providing the many 5MTHF groups for regeneration of MethylCo(III)B12

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